Pathophysiology | VTE Prophylaxis | VTE Treatment | Miscellaneous Facts |
---|---|---|---|
What is factor II (prothrombin)?
This clotting factor, which is the last factor that warfarin inhibits the synthesis of, has the longest half life.
|
What is fondaparinux (Arixtra)?
This medication, which is the only injectable factor Xa inhibitor available in the US, should not be used for surgical prophylaxis in patients under 50 kg.
|
What is 5mg SubQ once daily?
Patient is a 54 year old female weighing 47 kg. She has renal function and needs to be started on treatment dosing of Arixtra. This is her treatment dose.
|
What is a D-Dimer?
This is a product of fibrin degradation and is used in diagnosis to rule out DVT or PE.
|
What is Virchow’s Triad?
The understanding of many risk factors for vte can be associated with this model.
|
What is 5000 units SubQ BID?
This is the VTE prophylaxis dose of heparin, that should be given to a 76 year old female that weighs 68 kg.
|
What is Betrixaban?
This medication is not indicated for VTE treatment.
|
Double up on the 15 mg dose and take two, to ensure 30 mg is taken during the day.
Patient is on standard Xarelto dosing for VTE treatment. He is on day 4 and forgot to take his morning 15 mg dose and does not remember until it is time for his evening dose. The patient should…
|
What is Pulmonary embolism?
This severe and sometimes fatal condition can occur later in a patient with DVT that breaks off.
|
Patient should not be put on Savaysa due to the medication being CI in CrCl greater than 95 ml/min.
A 53 year old male patient who weighs 73 kg is going to be started on Savaysa for Afib ppx. Patient has great renal function, with a CrCl of 110 mL/min. This is his ppx dose of Savaysa.
|
What is at least 5 days of parenteral therapy?
Pradaxa is ordered for a patient for DVT treatment. This must have received this prior.
|
What is every 8 hours?
A patient on SCD should be assessed for skin integrity and neurovascular status of the extremity every __ hours.
|
What is antithrombin III (ATIII)?
This is what UFH binds to in order to cause a conformational change that leads to the inactivation of Factors IIa and Xa.
|
What is 110mg on day 1, then 220 mg daily for 28 to 35 days?
This is the prophylactic dose and duration of Pradaxa in THA/TKA in patients with good renal function and no drug interactions.
|
What is extended duration (indefinite)?
A patient experiences their first unprovoked DVT and they have a low bleeding risk. This is the duration of treatment.
|
What is dalteparin (Fragmin)?
The CLOT trial determined that this drug had improved outcomes of preventing recurrent VTE in the setting of malignancy when compared to warfarin.
|
What is clotting factor X?
Both the intrinsic and extrinsic pathways lead to the activation of this clotting factor.
|
What is 2.5 mg po BID?
Patient is an 82 year old female, weighs 58 kg and SCr is 0.9. She is receiving Eliquis for Afib ppx. This is her dose.
|
What is 70 mg SubQ once daily?
Lovenox is ordered for a 54 year old female for an acute DVT. She is 71 kg, 165 cm tall, and has a SCr of 1.2. This is her VTE treatment dose.
|
What is the CHA₂DS₂-VASc?
This scoring system is for patients with afib to determine risk of stroke.
|