| CBC | Signal Transduction | Analysis Techniques | Bone Marrow | Spleen |
|---|---|---|---|---|
|
What is a Complete Blood Count
What does CBC stand for?
|
Signal transduction
What is the process by which a cell transmits a signal from extracellular to intracellular?
|
To assess the tissues’ anatomy, composition, and role through visual analysis of sample
What is histology used for?
|
Blood production
What is the bone marrow’s function in the body?
|
One of the spleen’s main functions is filtering the blood and to produce lymphocytes when immune is compromised
What are the main functions of the spleen?
|
|
What are the basic components of a CBC panel?
What are Red blood cell count, White blood cell count, Hemoglobin, Hematocrit, Platelet
|
Dimerization and autophosphorylation
What changes does an RTK undergo upon binding of a ligand (e.g. growth factor)?
|
Uses fluorescent probes to target DNA sequences. Binding indices fluorescence that can be visualized
How does FISH work?
|
erythrocytes, b cells, t cells, nk cells, dendritic cells, granulocytes, macrophages, platelets
Name three types of blood cells made in the bone marrow
|
In situations where we have hematologic diseases
In what situations do splenomegaly develop?
|
|
What is to review overall health and help diagnose disease
Why do we order a CBC panel?
|
It competitively inhibits ATP binding to RTK’s tyrosine residue.
Explain the mechanism of how a TKI affects the RTK receptor.
|
Uses mRNA to create cDNA and identify genetic sequence location on chromosome
What is RT-PCR used for?
|
leukemia, sickle cell anemia
Name two diseases connected to the bone marrow
|
To treat the underlying disease e.g treat the CML
How is Splenomegaly treated?
|
|
What is it includes the types of white blood cells
A basic CBC differs from a CBC with differential in what way?
|
Tyrosine Kinase Inhibitors (TKI)
What are the main class of drugs given to patients with Chronic Myeloid Leukemia (CML)
|
Philadelphia 22 translocation. BCR-ABL gene
What gene sequence does RT-PCR probe for with CML.
|
Hematopoiesis
What is the process of blood production called?
|
6 ounces
What is the weight of an average adult human spleen?
|
|
What are Lymphocytes, neutrophils (promyelocyte, myelocyte, metamyelocyte), monocytes, basophils, eosinophils
What are the types of white blood cells included in a differential CBC?
|
G-proteins
RAS and RAF
In the signal transduction pathway of an RTK, what proteins serve as the transducer of the pathway? What are some examples of this protein?
|
1. myeloid/eosinophil granules: red
2. mast cell granules: purplish red 3. erythroid precursor cytoplasm: blue 4. plasma cell cytoplasm: purplish blue 5. perinuclear Golgi complex (hof) also seen as a pale area.
Normal histology of bone marrow will produce what stains?
|
osteoprogenitors- bone forming osteoblasts
The bone marrow cavity where hematopoiesis occurs contains specific types of cells at different stages of development, what are they called?
|
Yes, because the liver can take over many of the spleen’s functions.
Can you function without your spleen?
|
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