CBC Signal Transduction Analysis Techniques Bone Marrow Spleen
100
What is a Complete Blood Count
What does CBC stand for?
100
Signal transduction
What is the process by which a cell transmits a signal from extracellular to intracellular?
100
To assess the tissues’ anatomy, composition, and role through visual analysis of sample
What is histology used for?
100
Blood production
What is the bone marrow’s function in the body?
100
One of the spleen’s main functions is filtering the blood and to produce lymphocytes when immune is compromised
What are the main functions of the spleen?
200
What are the basic components of a CBC panel?
What are Red blood cell count, White blood cell count, Hemoglobin, Hematocrit, Platelet
200
Dimerization and autophosphorylation
What changes does an RTK undergo upon binding of a ligand (e.g. growth factor)?
200
Uses fluorescent probes to target DNA sequences. Binding indices fluorescence that can be visualized
How does FISH work?
200
erythrocytes, b cells, t cells, nk cells, dendritic cells, granulocytes, macrophages, platelets
Name three types of blood cells made in the bone marrow
200
In situations where we have hematologic diseases
In what situations do splenomegaly develop?
300
What is to review overall health and help diagnose disease
Why do we order a CBC panel?
300
It competitively inhibits ATP binding to RTK’s tyrosine residue.
Explain the mechanism of how a TKI affects the RTK receptor.
300
Uses mRNA to create cDNA and identify genetic sequence location on chromosome
What is RT-PCR used for?
300
leukemia, sickle cell anemia
Name two diseases connected to the bone marrow
300
To treat the underlying disease e.g treat the CML
How is Splenomegaly treated?
400
What is it includes the types of white blood cells
A basic CBC differs from a CBC with differential in what way?
400
Tyrosine Kinase Inhibitors (TKI)
What are the main class of drugs given to patients with Chronic Myeloid Leukemia (CML)
400
Philadelphia 22 translocation. BCR-ABL gene
What gene sequence does RT-PCR probe for with CML.
400
Hematopoiesis
What is the process of blood production called?
400
6 ounces
What is the weight of an average adult human spleen?
500
What are Lymphocytes, neutrophils (promyelocyte, myelocyte, metamyelocyte), monocytes, basophils, eosinophils
What are the types of white blood cells included in a differential CBC?
500
G-proteins
RAS and RAF
In the signal transduction pathway of an RTK, what proteins serve as the transducer of the pathway? What are some examples of this protein?
500
1. myeloid/eosinophil granules: red
2. mast cell granules: purplish red
3. erythroid precursor cytoplasm: blue
4. plasma cell cytoplasm: purplish blue
5. perinuclear Golgi complex (hof) also seen as a pale area.
Normal histology of bone marrow will produce what stains?
500
osteoprogenitors- bone forming osteoblasts
The bone marrow cavity where hematopoiesis occurs contains specific types of cells at different stages of development, what are they called?
500
Yes, because the liver can take over many of the spleen’s functions.
Can you function without your spleen?




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