Pharm Review Jeopardy Template

Opioids	Stimulants	Antidepressants	Antipsychotics	Other
100 Restlessness, yawning, rhinorrhea, lacrimation, piloerection What are the withdrawal symptoms of opioids?	100 Increase dopamine and norepinephrine in the CNS What is the MOA of amphetamines?	100 Inhibits 5-HT reuptake Fluoxetine, Fluvoxamine, Paroxetine, Sertraline, Escitalopram, Citalopram MOA of SSRIs? Name 1	100 Block D2 receptors MOA of first generation/typical antipsychotics?	100 Nephrogenic diabetes insipidus Adverse effect of lithium on kidneys
200 Altered mental status, decreased respiratory rate, decreased bowl sounds, miosis, seizures How would someone present if they overdosed on opioids?	200 1. Blocks Na+ channels 2. Inhibits reuptake of monoamines What is the MOA of cocaine? (2 answers)	200 Inhibits 5-HT and NE reuptake Venlafaxine, Desvenlafaxine, Duloxetine, Levomilinacipran, Milnacipran MOA of SNRIs? Name 2	200 Decrease 5-HT2A activity (significant serotonin blocking effects) MOA of second generation/atypical antipsychotics?	200 Ebstein's anomaly What is a fetal abnormality that may be caused by lithium use during pregnancy?
300 Naloxone Short acting opioid antagonist What medication would you give someone who overdosed on opioids?	300 Hyperalert, decreased need for sleep, tachycardia, HTN, pupillary dilation, fever, agitation, chest pain, seizures Signs of amphetamine intoxication?	300 Seizure, coma (due to antagonism of GABA) hyperthermia/skin flushing, dilated pupils and urinary retention (due to anticholinergic toxicity), hypotension (due to alpha blockade), prolonged QT How would someone present if they overdosed on TCAs?	300 Parkinsonian like symptoms, hyperprolactinemia Dry mouth, constipation, hypotension, sedation (because 5-HT, histamine, NE, and Ach may also be blocked because they are so structurally similar to dopamine) Side effects of first generation/typical antipsychotics?	300 Euphoria, increased appetite, slurred speech, impaired judgement, anxiety/panic attacks How would a patient on marijuana present?
400 CNS: Pain relief, euphoria, sedation, respiratory depression, cough suppression, miosis PNS: Constipation, skin warmth/flushing What are the CNS and PNS effects of opioids?	400 Increased energy, decreased need for sleep, hyperalert, euphoric, hallucinations (usually tactile), fever, anxiety, paranoia, dilated pupils, tachycardia, chest pain Signs of cocaine intoxication?	400 Infusion of sodium bicarbonate Sodium overcomes the NA+ blockade in heart Sodium bicarb raises pH -> favors inactive form of drug How would you treat an TCA overdose?	400 7-10 days after treatment is started pt will experience mental status changes, fever and rigid muscles. Labs will show increased creatinine kinase due to damaged muscles and myoglobinuria due to acute renal failure. What is neuroleptic malignant syndrome?	400 Euphoria, alertness, bruxism (teeth grinding), hyperthermia How would a patient on ecstasy present?
500 Presynaptic: Close Ca2+ channels (reduces neurotransmitter release) Postsynaptic: Open K+ channels (hyperpolarization) Overall Effect: Less signal transduction What is the MOA of opioids? (Presynaptic and postsynaptic)	500 Benzodiazepines Avoid beta blockers in cocaine intoxication because it can cause increased and unopposed alpha effects which can worsen HTN and chest pain How would you treat cocaine and amphetamine intoxication? *What should you avoid in cocaine intoxication?	500 MAO inhibitors Causes 3 A's Agitation, Autonomic hyperactivity, Neuromuscular hyperActivity Which antidepressant is a classic cause of serotonin syndrome?	500 Dantrolene (muscle relaxant) or bromocriptine (dopamine agonist) How do you treat neuroleptic malignant syndrome?	500 Synesthesia (hear colors), depersonalizations *Can see flashbacks after (Effects of LSD after stopping drug) How would a patient on LSD present?

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