The Basics | The Hepatoropic A,B,C's | The Other Bugs | Clinical Things | The Treatment! |
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What are viral infections?
These are the most common cause of hepatitis, but other etiologies include autoimmune, medications, toxins, alcohol.
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What is Hepatitis A?
This type of hepatitis is due to a single-stranded, nonenveloped RNA of the Picornaviridae family and transmitted via the fecal oral route.
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What is EBV?
This virus typically causes infectious mononucleosis, but can progress to acute hepatitis, which is usually self-limiting.
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What is increasing AST/ALT?
These are common lab findings early in hepatic injury.
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What is Hepatitis A?
Patients suffering from this infection may be contagious for 2 weeks before and 7 days after the onset of jaundice and require good washing after toileting.
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What is acetaminophen?
This commonly used medication causes a direct toxin induced necrosis as the mechanism of injury.
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What is Hepatitis E?
This virus is a single-stranded non enveloped virus of the Hepeviridae virus and usually is self-resolving although can lead to fulminant liver failure.
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What is CMV?
This infection is typically associated with neurological abnormalities, and classic periventricular calcifications found on head imaging, however it is also a cause of hepatitis with over 60% of infants have jaundice and hepatosplenomegaly.
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What is rapidly falling AST/ALT?
This is a poor prognostic indicator of liver injury.
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What is Hepatitis B?
Screening mothers for this virus prior to delivery is an important key to preventing transmission to the newborn in this illness.
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What is vertical transmission from infected mothers?
This is the most common mechanism for newborns to contract hepatitis.
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What is Hepatitis B?
This virus is an enveloped DNA virus that is a member of the Hepadnaviridae family and has an infection rate among exposed infants with infected mothers who do not receive any form of prophylaxis.
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What is Adenovirus?
This virus may typically cause viral upper respiratory tract symptoms in children, however in 2022 there was a world wide outbreak in which children were progressing to fulminant liver failure and some even required liver transplant!
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What is hypoalbuminemia and increased PT/INR.
These lab values indicate that hepatic synthetic function is altered.
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What is Hepatitis A?
Postexposure prophylaxis with Immune Globulin Intramuscular is more than 85% effective in preventing symptomatic infection in this illness when given within 2 weeks of exposure.
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What is activation of the innate and adaptive immune systems?
This is the mechanism of injury for liver injury due to viral etiologies.
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What is Hepatitis C?
This virus is a small, single-stranded, enveloped RNA virus that is a member of the Flaviviridae family and vertical transmission is the primary source of pediatric infection.
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What is Dengue Virus?
This is the most rapidly spreading mosquito-borne viral disease in the world and an estimated 50 million infections occur annually, and can cause severe hepatitis in pediatric patients as it progresses.
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What is Hepatitis B?
This infection causes extrahepatic manifestations due to circulating immune complexes such as arthralgias, arthritis, polyarteritis nodosa, thrombocytopenia, and glomerulonephritis.
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What is interferon alfa or lamivudine (B) or ribavirin (C)?
Hepatitis B & C may cause chronic illness, however, treatment is available with these medications.
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What is 3 months?
With recovery from infection, liver morphology can return to normal in...
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What is Hepatitis D?
This virus is caused by a RNA virus, and requires hepatitis B virus (HBV) as a helper virus
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What is Herpes Simplex Virus?
This infection has a wide variety of presentations including vesicular skin lesions or CNS infections, however, it can also lead to multi-organ failure, with severe hepatitis and liver failure.
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What is Hepatitis A and Hepatitis B?
These are two hepatotropic vaccines recommended in childhood.
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What are severe vomiting and dehydration, altered coagulation, or hepatic encephalopathy?
These are indications for hospitalization of children with acute hepatitis.
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