Anatomy 101 | It's A Chemical Thing | It Does Exist! | Getting From Here to To There | Things That Make You Go |
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Dorsal Horn
In the processing of pain, primary afferent neurons synapse in
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Calcium
Activation of the NMDA receptor results in an influx of this ion
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Nociceptors
These are free nerve endings which help transduce painful stimuli into impulses
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C fibers
Unmyelinated fibers which carry pain signals
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Pain
An unpleasant sensory and emotional experience associated with actual or potential tissue damage
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Lamina of Rexed
The gray matter of the spinal cord is divided into 10
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Alogens
This group of pain producing substances can activate nociceptors
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Brain
Unlike it's meningeal coverings, this organ does not contain nociceptors
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Alpha-delta fibers
Sharp, well-localized pain is mediated via
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Supraspinal level
Modulation of pain can occur peripherally, at the spinal cord level and
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Contralateral thalamus
Second order neurons project from the dorsal horn to this structure where they synapse with third order neurons
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Substantia gelatinosa
The primary site of action for opiates in the spinal cord
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Cerebral cortex
This portion of the brain is the site of perception and discrete localization of pain
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Silent nociceptors
These receptors are only activated in the presence of inflammation
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Gate theory
Activation of large afferent fibers inhibiting WDR neurons and spinothalamic tract activity supports this theory of pain processing
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Spinothalamic tract
Pain impulses are sent from the spinal cord to the brain via the
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Alpha 2
In the monoamine inhibitory pathway, NE acts on these receptors to mediate an anti-nociceptive effect
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Windup
In this phenomena, repeated stimuli of the same intensity result in exponentially increasing firing rates
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Attention
Perception of pain involves two main components: cognition and this, which is the basis behind hypnosis and biofeedback
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Anterior horn
Some primary afferents do not synapse in the dorsal horn, but in this region to mediate withdrawal reflexes
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Periaquaductal gray matter
The reticular formation, nucleus raphe magnus and this structure are involved in the process of supraspinal inhibition of pain
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Substance P
In the opiate descending inhibitory pathway, hyperpolarization of the alpha-delta and c fibers inhibits the release of
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Referred
The convergence of visceral and somatic afferent input in laminas I and V result in this type of pain
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Wide dynamic range
These second order neurons carry signals for both noxious and non-noxious stimuli and are involved in spinal windup
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Receptor field expansion
Process in the dorsal horn where previously unresponsive neurons become responsive to both noxious and non-noxious stimuli
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Billy Ray Cyrus
The pain in this singer's "Achy Breaky Heart" would be considered visceral pain, while being hit by a "Wrecking Ball" would likely produce a good amount of somatic pain
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