Oncotype Dx Double Jeopardy Jeopardy Template

General	Node negative	Node Positive	Clin / Path features	Role Plays
100 RT-PCR How is the technique used for ODX test processing?	100 What are the validation studies in N0 setting? What are the validation studies in N0 setting?	100 What are the node positive studies? TransATAC SWOG RxPONDER What are the node positive studies?	100 Grade 1, size >3 Grade 2, size >2 Grade 3, size >3 What is the definition of clinical High risk in TAILORx?	100 TailorX Newbie - N0
200 21 genes How many genes is the panel of ODX?	200 28% What is the absolute chemotherapy benefit in B20?	200 inclusion of the age and relevance to CT benefit in primary endpoint ARM A & D excluded from the study Pre-defined cut points for menopausal status no statistical significant iDFS difference between two subgroups Name 2 differences between TAILORx and RxPONDER	200 43% What is the percentage of patients that presented with high clinical risk but fell in low risk category with ODX - TAILORx?	200 RxPONDER RxPONDER Newbie - N1
300 Level 1b What is the level of ODX data in NSABP-B20?	300 6.5% For a RS of 23 for a pre-menopausal women, what is the CT benefit?	300 2.9% What is the benefit of CT for pre-menopausal women in RxPONDER	300 N0/ N1 post-menopausal , more than 0.5 cm Who is eligible for ODX according to NCCN guidelines?	300 Patient centricity Patient centricity User - N0 Clinical path features (general)
400 What is the level of ODX data after RxPONDER and TailorX? Level 1a What is the level of ODX data after RxPONDER and TailorX?	400 13% What is the distance recurrence rate for the ARM D in TAILORx?	400 How is menopausal status defined in RxPONDER? pre-menopausal: less than 6 months since the last period post-menopausal: more than 12 month since last period How is menopausal status defined in RxPONDER?	400 No longer put to vote - not recommended Where does St Gallen stands when it comes to incorporation of ki-67 in treatment paradigm	400 patient centricity patient centricity ki-67 driver for ODX prescription USER
500 1-10 According to the 8th pathologist association criteria, which RS range recategorizes the patient from stage 2 to stage 1	500 Primary: IDFS Secondary: OS, DRFI Primary: IDFS Secondary: OS, DRFI What are the primary and secondary endpoints in TAILORx?	500 Primary: iDFS with adjustment in menopausal status Secondary: OS What are the endpoints in RxPONDER?	500 Node status Ki-67 Age Tumor Size Grade Clinical H/L All In the German study what were the stratification of patients	500 :) Oncotype is not for everyone as it is expensive

Oncotype DX double Jeopardy

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