DNA, Cells, Protein

murine

Formed by more than one polypeptide chain interacting and folded to make a multi-subunit complex. Examples include protein dimers, trimers etc.

Term used for single chain antibody fragment. It consists of covalently linked heavy and light chain of the antigen-binding region (tip of the arm).

Trastuzumab (Herceptin) is this type of mAb

protein manufacturing
diagnosis
treatment

chimeric

occurs when sequence of amino acids are linked by hydrogen bonds

Term used for fragment that contains one arm of the antigen-binding region.

This would most likely produce the highest incidence of ‘human anti-mouse antibody’ response

using radioactive or fluorescent DNA fragments

completely human

Functional/Biological activity
Stability
Immunogenicity
Pharmacokinetics

Term used for variable region of antibodies. This is the region that binds to antigens

Products designed to block protein synthesis using modified DNA or RNA that are a complementary copy of sense oligonucleotides. These oligonucleotides bind to sense copies, thereby preventing steps necessary for protein production.

This therapy uses cells to treat a disease

5% mouse
95% human

Hydrophobic interactions
Hydrogen Bonds
Salt bridges
Disulfide bonds (covalent bonds)

Term used for crystallizable fragment of antibodies. Contains the constant domain mAbs which binds to Fc receptors and complement proteins, thereby propagating the immune response

Generic name for Trandate?

hormones
clotting factors
cytokines

Class of monoclonal antibodies that makes up the majority of antibodies in the serum as well as commercial mAb products

A less folded protein is more likely to be spotted by the immune system cells and generate an immune response

Term used for fragment that contains both arms of the antigen-binding regions

the most common route of administration for biotechnology products