| Mechanism of action | Drug interactions | Side effects | PK/PD | Mystery! |
|---|---|---|---|---|
|
What is a tacrolimus?
Which drug works by binding to FKBP-12, forms a complex with calcineurin, and prevents dephosphorylation of NFAT?
|
What is CYP3A5
Name the major CYP enzyme tacrolimus is metabolized through
|
What is osteopenia/osteoporosis, weight gain, cushing syndrome, infection, impaired wound healing, glaucoma, GI bleed or ulcer, growth suppression, Epistaxis, Kaposi's sarcoma, adrenal insufficiency
Name 2 long term effects of corticosteroids
|
What is Gengraf
Which formulation has better absorption, Gengraf or Sandimmune?
|
What is every 4 weeks?
In the maintenance dosing phase of belatacept, how often are the infusions?
|
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What are sirolimus and everolimus?
Name the two drugs that bind to the mammalian target of rapamycin
|
What are NSAIDs
What is the class of over the counter pain medications that patients should avoid while on a CNI based regimen?
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What is false
True/false: Switching from mycophenolate mofetil to mycophenolic acid will always help a patient who has drug associated diarrhea.
|
What is false
True or false: tacrolimus absorption is not affected by food
|
What are mTOR inhibitors
Which class of drugs is associated with mouth ulcers?
|
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What is binds to cyclophilin, interferes with activity of calcineurin
What is the mechanism of action of cyclosporine?
|
What is febuxostat?
Which drug is absolutely contraindicated with azathioprine?
|
What is false
True or false: mycophenolate causes leukopenia, but does not anemia
|
What is 5-7 days
After adjusting an everolimus dose, how long before trough will reflect new dose?
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What is azathioprine
Which drug is metabolized by TPMT?
|
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What is the T-cell costimulation blocker, binds to CD80/86 to prevent activation of lymphocytes
What is the mechanism of action of belatacept?
|
What is OATP1B1
Through which enzyme do cyclosporine and statins interact (not CYP)?
|
What is everolimus or sirolimus
A patient reports new onset shortness of breath. A chest CT demonstrates interstitial lung disease. Which drug discussed today could cause this side effect?
|
What is 6-TGN
Name the metabolite responsible for the myelosuppressive effect of azathioprine
|
What is true
True/false: mycophenolate can interfere with the effectiveness of oral contraceptives
|
|
What is mycophenolate?
Which drug inhibits inosine monophosphate dehydrogenase, blocking purine synthesis?
|
What is an ace inhibitor?
Which class of drugs can cause angioedema when in combination with an mTOR inhibitor?
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What is PTLD
Starting belatacept in a patient who is EBV seronegative puts them at increased risk for what side effect
|
What is 62 hours
What is the half life of sirolimus in a patient with normal hepatic function- 12 hours, 24 hours, 62 hours, or 113 hours?
|
What is 1:2?
What is the most common conversion ratio from oral to sublingual tacrolimus?
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