Decreased formation of prostaglandin precursors by irreversible inhibition of cyclooxygenase-1 and 2 enzymes and thromboxane A2

Adrenal suppression, hypertension, dyslipidemia, fluid retention, psychiatric disturbances, Cushing syndrome, peptic ulcer, dyspepsia, gastritis, abdominal distention, weight gain, increased appetite, hyperglycemia, infection, osteoporosis, myopathy, increased intraocular pressure, glaucoma, thinning of the skin, impaired wound healing