| Blood and lymph 1 | Blood and lymph 2 | Blood and lymph 3 | Blood and lymph 4 | Blood and Lymph 5 |
|---|---|---|---|---|
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The Primary role of blood is transporting heat and molecules
What is the primary function of blood?
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7% , 25%
What percentage of your body weight is taken up by blood? and what percent of the ECF?
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B12 and Folic acid
What are the two elements RBC maturation is dependent on?
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Iron
what does the body reuptake from burst cells after hemolysis?
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Blood viscosity decreases meaning a decrease in resistance to flow, which allows too much blood flow = increase in Cardiac output
Why is anemia bad?
|
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Blood transfers heat from warmer to cooler parts of the body as well as excess heat to the skin
What is heat transfer?
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Plasma contains more protein due to proteins inability to pass through tight junctions in the ISF
What are the differences between plasma and ISF?
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Intrinsic factor, IF is a glycoprotein produced by parietal cells in the GI tract and necessary for B12 absorption
What triggers the absorption of b12? and what is it?
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Hemorrhage, High altitude, Physical activity, anemia
What're 4 causes of hypoxia?
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A genetic mutation that leads to a 30% increase in RBC production
What is polycythemia vera?
|
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Plasma and cellular elements, 7%
What are the two components of blood? and what percentage of plasma is made of protein?
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Hemoglobin transport, and is regulated by cytokines, growth factors, and transport factor
What are the major functions of RBCs? and how is it regulated?
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The liver
What major organ is b12 stored in?
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Anuclear, They contain glucose and ATP to last 120 days
What are the characteristics of an RBC? and how long do they last?
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-More resistance flow
-Decrease in venous return due to blood staying in tissue longer -Hypertension
Why is polycythemia bad?
|
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RBCs - transport gasses and contains hemoglobin for O2 transport
WBCs - immune system
What is the function of RBCs and WBCs?
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Hematopoiesis, produced in the bone marrow it is tightly regulated to make sure viscosity stays consistent as to not impede flow.
What is the term for controlling RBC production? and how does it work?
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EPO expression occurs within minutes to hours of the kidneys sensing hypoxia, However, it takes 5 days before new RBCs enter and is sustained until enough RBCs have been produced to no longer trigger hypoxia
Explain the whole function of EPO, and when it activates?
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When RBCs are destroyed by passing through the spleen where the narrowest capillaries of 3 microns burst decaying old RBCs
What is hemolysis?
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mostly involved in resistance to infection and immunity
What is the purpose of WBCs?
|
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The ratio of RBCs to the total blood volume
Hormones drive differences in RBCs in men and women which affects O2 levels Less dense at the top
What is Hematocrit? What does it change in men and women? Where is it most dense?
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The production of Hypoxia-inducible factor 1 (HIF-1) turns on, then HIF-1 binds the response element on erythropoietin (EPO), EPO expression increases which leads to cytokines, something that we produce when needed
What happens when the kidneys sense hypoxia?
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Liver, Spleen, and lymph nodes. Then bone marrow.
What part of the body is responsible for the growth production of RBCs before and after gestation?
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1. Aplasia, radiation, autoimmune disease
2. maturation failure - iron, B12, or folic acid deficiency 3. Sickle cell
What are the causes of anemia?
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the passage of blood cells through the intact walls of the capillaries, typically accompanying inflammation.
What is diapedesis?
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