A gene associated with hereditary breast and ovarian cancer syndrome, including the elevated chance to develop melanoma.

Surgical procedure to remove the ovaries and fallopian tubes.

A method of error-free, double stranded DNA damage repair.

Biallelic mutations are associated with a 43-100% chance of developing colorectal cancer.

A family-history weighted prediction algorithm providing 5, 10, and lifetime remaining risks to develop breast cancer.

Defined as having greater or equal to 100 polyps with nearly 100% risk of developing colon cancer.

Limited by the inability to detect low level mosaicism.

The use of medication to lower the risk or prevent cancer in healthy people.

Hereditary predisposition syndrome related to an increased risk for ovarian neoplasms, including adenocarcinomas and sex cord tumors.

Deletions disrupting the 3’ end of the gene leads to transcriptional read-through of the mutated allele and epigenetic inactivation, and silencing of, its neighboring gene MSH2.

A risk prediction algorithm based on variation in multiple genetic loci.