Fun 2 25 Antivirals Jeopardy Template

Mechanism of Action	Resistance	Drug class	Miscellaneous	Miscellaneous
100 They interfere with post-translational modification of viral proteins. Thus, mature virus is not produced How do protease inhibitors work?	100 Mutations in RTase How do viruses develop resistance against non-nucleoside RTIs (Nevirapine)	100 Fusion Inhibitor Enfuvirtide is a?	300 IFN alpha and beta These viral transcription inhibitors are also antiviral components produced by our body.	300 2. Acyclovir Triphosphate Acyclovir is an RNA/DNA replication inhibitor. It is phosphorylated by viral kinases into ________, which competes with dGTP, to terminate the DNA chain 1. Acyclovir tetraphosphate 2. Acyclovir triphosphate 3. Acyclovir pentaphosphate 4. Acyclovir
200 Integrase inhibitors Which class of drug would you administer to inhibit the incorporation of HIV DNA into the host cell's DNA	100 Mutations in RTase How do virsues develop resistance against Nucleoside Reverse Transcriptase Inhibiitors (Zidovudine)	200 non-nucleoside RTIs Saquinavir and Ritonavir are?	300 b. Binding of the virus to host cell Hemagluttinin is a glycoprotein responsible for: a. Release of virus from host cell b. Binding of the virus to host cell c. Viral transcription d. Protosomeal degradation	400 Uncoating inhibitors = 150 Amantadine = 150 This drug, apart from inhibiting M2 proton channels, is also used to treat Parkinson's disease.
300 Miravoric This drug is a non-competitive antagonist of the co-receptor CCR5	100 Mutations in M2 proton channel How do viruses develop resistance towards Amantadine (uncoating inhibitor)	300 Zidovudine An example of a nucleoside Reverse Transcriptase Inhibitor is?	200 T helper cells on CD4 receptors HIV virus affects which cells? which receptor does it bind to?	200 a. 200 μl AIDS is defined by a T cell count of less than? a. 200 μl b. 500 μl c. 300 μl d. 1000 μl
400 They are metabolised to triphosphate, and used by DNA polymerase to form a 'faulty DNA' as the nucleosides are replaced by the drug. Ziduvidine is a nucleoside Reverse transcriptase inhibitor. How does it inhibit Reverse Transcriptase? How does it differ from Non-nucleoside RTIs?	100 Mutations in viral protease enzyme How do viruses develop resistance against protease inhibitors (Ritonavir)	400 Integrase inhibitors Raltegravir and Elvitegravir belong to which class of antiretroviral drugs?	300 CCR5 and CXCR4 Name the two co-receptors which HIV strains bind to on T helper cells	400 e. H. pylori Which of the following is NOT an opportunistic infection that defines AIDS a. Kaposi's Sarcoma b. Candida c. Cryptococcus d. Pneumocystis Jerovicii e. H. pylori
500 M2 proton channels. This channel is required for viral uncoating. It pumps protons to the interior of the endosome containing the virus, resulting in dissociation of viral nucleic acid.? Amantadine inhibits uncoating of viral nucleic acid. What does amantadine block? and why?	300 FREE POINTS CONGRATS	500 Tamiflu, Zanamivir Neuramidase inhibitors target neuramidase, which is required for viral release from the host cell. Which drug would you use to target this enzyme.	300 1. A Amantadine is an uncoating inhibitor used for influenza... 1. A 2. B 3. C 4. D	300 d. Sialic acid (neuraminic acid) Neuramidase is a viral enzyme which cleaves _______ on the host's cell, to help release the virus. a. Hemagluttinin b. Protease c. Glucoronic acid d. Sialic Acid

FUN 2-25: Antivirals

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