The number of transmembrane domains in WT EAATs

This function of EAATs is stoichiometrically uncoupled from glutamate transport

Anion transport increases when this molecule is present

This EAAT was thought to be uniquely localized to the retina

This bacterial analogue has ~40% homology with human EAATs

2 disorders implicated in EAAT dysregulation

This EAAT is responsible for ~90% of glutamate clearance in the brain

These two EAAT isoforms are primarily present in neurons

The quaternary structure of EAATs

This drug causes EAAT3 internalization in dopamine neurons

These ions are co-transported with glutamate

Where EAAT4 is primarily found

This functional region is implicated in anion channel gating

This splice variant results in negative regulation of full length EAAT function

This kinetic trait supports the hypothesis of anion transport as a primary function of EAATs 4 and 5

This EAAT may be upregulated neuronally where astroglia are absent

This gene encodes EAAT2

These three transmembrane domains are part of the functional transport domain in EAATs

Although exact function is unclear, this functional domain may related to transporter retention time within the plasma membrane

Specifically, EAATs 3 and 4 are more highly concentrated in this area of the synapse