humanized monoclonal antibody directed against
integrin molecules expressed on the cell surface of leukocytes

May cause pancreatitis and bone marrow suppression

First line therapy for mild to moderate ulcerative colitis

inhibitor of lipoxygenase pathway

The adverse effects of this drug include Stevens-Johnson syndrome, hepatitis, pneumonitis, hemolytic anemia and bone marrow suppression

effective in perianal or fistulizing Crohn’s disease and pouchitis

chimeric monoclonal antibody combining portions of
mouse and human IgG directed against TNF-α.

May cause increased intraocular pressure and cataracts

used only in patients who
have not responded to other drugs, including a TNF inhibitor