Coag Cascade Anticoagulants-Mechanism of action Coagulation tests Coag Trivia PK/PD
100
What is tissue factor and factor VII?
These two clotting factors start the extrinsic pathway.
100
What is warfarin?
Inhibition of factors II, VII, IX, X
100
What is PT-INR?
My patient on warfarin is coming back today for this blood test.
100
What is warfarin?
This drug has roots in Wisconsin
100
What is enoxaparin?
Anticoagulant cleared only by the kidney
200
What is clotting factor VIII?
This factor acts as a cofactor in the activation of factor
X.
200
What is fondaparinux?
Indirect inhibition of factor Xa only
200
What is aPTT (activated partial thromboplastine time)?
The nurse paged the pharmacist for recommendations for adjustment of heparin for this test results of 90seconds.
200
What is aPTT?
This coagulation test was developed in UNC
200
What are rivaroxaban and apixaban?
Anticoagulant/s metabolized by hepatic CYP 450 3A4
300
What is clotting factor V?
This factor acts as a cofactor in the activation of factor
II.
300
What are heparin, enoxaparin?
Indirect inhibition of factors IIa and Xa
300
What is enoxaparin?
Anti-Xa activity level is used to monitor this drug,
target level is 0.6-1.0 if it is give twice daily
300
What is hemophilia?
In the second century, Rabbi Judah haNasi,
redactor of the Mishneh, wrote in the Babylonian
Talmud: "If she circumcised her first child and he died, and a second one also died, she must not circumcise her third child."
300
What is warfarin?
Anticoagulant/s metabolized by hepatic CYP 450 2C9
400
What is clotting factor XIII?
This factor stabilizes the fibrin crosslink
400
What are rivaroxaban, apixaban, edoxaban?
Direct inhibition of factor Xa
400
What is dabigatran?
Sheh-Li would recommend ECT to determine whether
there is any of this drug remaining in the patient.
400
What is Christmas disease, aka hemophilia B?
This bleeding disorder is named after a holiday.
400
What is heparin?
Anticoagulant/s metabolized by reticuloendothelial cells
500
What is plasmin?
Fibrin is broken down by this
500
What are argatroban, bivalirudin, dabigatran?
Inhibition of factor IIa
500
What is heparin anti-Xa level?
This test should be used to monitor heparin for
patients with anti-phopholipid antibodies with a
prolonged aptt at baseline
500
Who is Erik von Willebrand?
This Finnish physician treated a 5yo girl with an
extensive family history of bleeding, and discovered
23 of the girl's 66 family members were affected, and most of them were women
500
What is clotting factor VIII?
The level of this clotting factor is not low in liver failure






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