Coag Cascade | Anticoagulants-Mechanism of action | Coagulation tests | Coag Trivia | PK/PD |
---|---|---|---|---|
What is tissue factor and factor VII?
These two clotting factors start the extrinsic pathway.
|
What is warfarin?
Inhibition of factors II, VII, IX, X
|
What is PT-INR?
My patient on warfarin is coming back today for this blood test.
|
What is warfarin?
This drug has roots in Wisconsin
|
What is enoxaparin?
Anticoagulant cleared only by the kidney
|
What is clotting factor VIII?
This factor acts as a cofactor in the activation of factor
X. |
What is fondaparinux?
Indirect inhibition of factor Xa only
|
What is aPTT (activated partial thromboplastine time)?
The nurse paged the pharmacist for recommendations for adjustment of heparin for this test results of 90seconds.
|
What is aPTT?
This coagulation test was developed in UNC
|
What are rivaroxaban and apixaban?
Anticoagulant/s metabolized by hepatic CYP 450 3A4
|
What is clotting factor V?
This factor acts as a cofactor in the activation of factor
II. |
What are heparin, enoxaparin?
Indirect inhibition of factors IIa and Xa
|
What is enoxaparin?
Anti-Xa activity level is used to monitor this drug,
target level is 0.6-1.0 if it is give twice daily |
What is hemophilia?
In the second century, Rabbi Judah haNasi,
redactor of the Mishneh, wrote in the Babylonian Talmud: "If she circumcised her first child and he died, and a second one also died, she must not circumcise her third child." |
What is warfarin?
Anticoagulant/s metabolized by hepatic CYP 450 2C9
|
What is clotting factor XIII?
This factor stabilizes the fibrin crosslink
|
What are rivaroxaban, apixaban, edoxaban?
Direct inhibition of factor Xa
|
What is dabigatran?
Sheh-Li would recommend ECT to determine whether
there is any of this drug remaining in the patient. |
What is Christmas disease, aka hemophilia B?
This bleeding disorder is named after a holiday.
|
What is heparin?
Anticoagulant/s metabolized by reticuloendothelial cells
|
What is plasmin?
Fibrin is broken down by this
|
What are argatroban, bivalirudin, dabigatran?
Inhibition of factor IIa
|
What is heparin anti-Xa level?
This test should be used to monitor heparin for
patients with anti-phopholipid antibodies with a prolonged aptt at baseline |
Who is Erik von Willebrand?
This Finnish physician treated a 5yo girl with an
extensive family history of bleeding, and discovered 23 of the girl's 66 family members were affected, and most of them were women |
What is clotting factor VIII?
The level of this clotting factor is not low in liver failure
|