| To Kill or Not to Kill | The Family Founder | The Family | The Inhibitors |
|---|---|---|---|
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What is extrinsic
Apoptosis can be induced via the death receptor mediated or ______ pathway.
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What is the mitochondrial outer membrane
Where in the mitochondria is BCL2 localized to?
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What is BCL2, MCL1, BCLxL, BCLw, and BCL2A1
Which proteins make up the anti-apoptotic Bcl-2 family of proteins? (Hint: there are 5)
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What is BH3-mimetics
BCL2 inhibitors are also called?
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What is intrinsic
Apoptosis can be induced via the mitochondrial or ______ pathway.
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!DAILY DOUBLE!
What is chromosome 14 and 18
The founding member of the family, BCL-2 was identified as an oncogene resulting from a translocation between which chromosomes?
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What is Bad, Bik, Bim, Bmf, Noxa, Puma, and Bid
Which proteins make up the pro-apoptotic BH3-only Bcl-2 proteins? (Hint: there are 7)
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What is cardiotoxicity
This off-target effect of the MCL1 inhibitor AMG-397 caused the FDA to place the clinical trials on hold
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What is apoptosis
What is a genetically programmed cell death that maintains tissue homeostasis?
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What is follicular lymphoma
The founding member of the BCL2 protein was identified in which type of lymphoma?
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What is Bax, Bak, and Bok
What are the pro-apoptotic effectors? (Hint: there are 3)
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What is thrombocytopenia (BCLxL restrains BAK to maintain platelet survival)
This adverse effect has limited widespread use of agents that target BCL-xL.
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What is senescence
What is the cellular process of arresting cells in a non-dividing, but metabolically active state?
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What is the BCL-2 homology (BH) domain
The BCL-2 family proteins can be classified based on their structure and _____.
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What is the Cytosol (the transmembrane domain of BAX is inside of/sequestered in the hydrophobic groove, thus it sits in the cytoplasm/cytosol and is not on the mitochondrial membrane)
Under normal conditions, where is unactivated BAX located in the cell?
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What is mutations in BCL2 (eg, Gly101Val, Asp104Tyr), overexpression of MCL1, and overexpression of BCLxL
List three mechanisms of resistance to BCL2 inhibitors
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What is Rb/p16 and p53/p21
What are the two major tumor suppressor pathways known to govern senescence?
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What is the BH3 domain
What BH domain is conserved among all members of the BCL2 family proteins and is essential for the interaction between the BCL2 family proteins?
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Alpha 3, 4, and 5
Which alpha helices does venetoclax bind to?
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BID
Which BCL2 family protein can be activated by the extrinsic apoptosis pathway to amplify the intrinsic apoptosis pathway?
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