Amenorrhea Jeopardy Template

Clinical Presentations	Treatments	Pathophysiology	Lab Values	Miscellaneous
100 What is hyperprolactinemia G0P0 30yo, B-HCG negative female presents with amennorhea and galactorrhea	100 What is adenoma removal and control of cortisol production/tissue response Cushing's Syndrome	100 What is Turner's Syndrome Failure to produce estrogen/progesterone due to lack of ovaries/functional follicles	100 What is premature ovarian failure (Turner's Syndrome) Low estrogen, High FSH and LH	100 What is failure Predict Progesterone Challenge and Estrogen Progesterone Challenge Results: Androgen Insensitivity Syndrome
200 What is androgen insensitivity syndrome 46 XY 17 yo female (with normal, shallow vagina) presents with amenorrhea, dyspareunia, exam shows scant pubic hair	200 What is Asherman's syndrome hysteroscopic lysis of adhesions	200 What is a defect in androgen receptors in XY embryo leads to development of secondary female sex characteristics despite primary (immature) XY sex characteristics (i.e. undescended testicles). Presence of shallow vagina because last 1/3 of vagina is ectod Androgen Insensitivity Syndrome	200 What is high prolactin, decreased FSH, LH, estrogen, progesterone hyperprolactinemia	200 What is secretion of B-HCG, surrounds terminal buds of chorionic villi to separate maternal and fetal blood supply Role of syncytiotrophoblast in pregnancy
300 What is Turner's syndrome 17 yo 4'8" female presents with primary amenorrhea secondary to delayed puberty, ultrasound reveals ovarian streaks	300 What is Turner's Syndrome Estrogen therapy until age 15 yo birth control pill (HRT) >15 yo IVF if desire to become pregnant	300 What is abnormal fibrosis of uterus post-trauma Asherman's Syndrome	300 What is high ACTH, low FSH, LH, estrogen, progesterone Cushing's syndrome	300 What is failure of progesterone, bleeding after estrogen-progesterone challenge. Predict Progesterone Challenge and Estrogen-Progesterone Challenge Results: Turner's Syndrome
400 What is Cushing's syndrome 30 yo female, chief complaint amenorrhea, also complains of weight gain in the stomach area, exam shows hypertension, blood work hyperglycemia	400 What is hormone replacement, gonadectomy of cryptorchid testes (can be cancer causing if left untreated) Androgen Insensitivity Syndrome	400 What is Cushing's Syndrome Increased cortisol production causing negative feedback to HPG axis, decreasing GnRH pulsatility. Additional androgenic excess due to overstimulation of adrenal cortex	400 What is Asherman's syndrome blood work is normal	400 What is osteoprotegerin Provides "decoy" receptor for RANKL in bone growth and repair, is upregulated by estrogen.
500 What is Asherman's Syndrome 25 yo female presents with amenorrhea persisting 4 months post abortion, fails both the progesterone challenge and the estrogen-progesterone challenge	500 What is hyperprolactinemia adenoma removal, dopamine agonist (inhibitory to a specific hormone in anterior pituitary)	500 What is Hyperprolactinemia Prolactinoma causing increased prolactin secretion resulting in negative feedback to HPG axis	500 What is high estrogen, LH, testosterone	500 What is inhibition of osteoblast activity, promoter of osteoclast activity via decrease in osteoprotegerin, upregulation in RANKL glucocorticoids affect on bone growth

Amenorrhea

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